DiscoverPeptides for WomenEpisode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep
Episode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep

Episode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep

Update: 2025-08-15
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Welcome back to the Peptides for Women podcast, my little 80s babes! 

Today we’re digging into two of the most fascinating (and fun to say!) peptides: Tesamorelin and Ipamorelin.

Both of these peptides help your body make more growth hormone, which naturally declines in your 30s, 40s, and 50s. And since growth hormone is the secret sauce for lean muscle, fat loss, skin, sleep, and recovery, this is a conversation you don’t want to miss.

In this episode, I break down:

  • What tesamorelin and ipamorelin actually do in your body (and how they’re different)

  • Why tesamorelin is especially powerful for midlife belly fat and body composition

  • The “thermostat vs. tap” analogy to help you understand their unique roles

  • How ipamorelin supports deep sleep, recovery, and mood—without messing with other hormones

  • What the research really says about fat loss, muscle, and brain health

  • How these peptides can be used together for even better results

  • The importance of healthy foundations (protein, lifting, sleep, sun, steps) before adding peptides

I’ll also share why I’m personally so excited to add tesamorelin into my own peptide stack, plus a few stories from clients and from my husband, Beau, who’s already seen incredible results with sermorelin.

📘 Resources Mentioned:


1. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial

https://pubmed.ncbi.nlm.nih.gov/25038357/


2. Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity

https://pubmed.ncbi.nlm.nih.gov/39813152/


  • 3. Tesamorelin Modestly Reduces Liver Fat

  • https://www.jwatch.org/na35376/2014/08/08/tesamorelin-modestly-reduces-liver-fat


  • 4. Ipamorelin, the first selective growth hormone secretagogue

  • https://pubmed.ncbi.nlm.nih.gov/9849822/


  • 5. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats

  • https://pubmed.ncbi.nlm.nih.gov/10828840/


  • 6. The role of peptides in bone healing and regeneration: a systematic review

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC4940902/


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    Episode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep

    Episode 5: Tesamorelin vs. Ipamorelin | Peptides for Growth Hormone, Fat Loss, and Better Sleep

    Jennifer Woodward